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For people with Down syndrome, family members, caregivers and professionals.

Medications for Weight Loss

July 2022 | Brian Chicoine, MD - "Ask Dr. Chicoine" LuMind IDSC Foundation

The parent of an individual with Down syndrome asked a question about medications to treat obesity in a person who has not been significantly successful with diet and exercise despite many efforts. I have shared my response below.

Obesity and overweight as measured by body mass index (BMI) are more common in people with Down syndrome (DS). BMI, the measurement commonly used to assess weight status, is a calculation based on height and weight. A score of 18.5 to 24.9 is considered normal, 25-29.9 is “overweight,” 30-34.9 is class 1 obesity, 35-39.9 is class 2 obesity, and 40 and above is class 3. However, there is ongoing study and discussion as to the accuracy of BMI as a measurement in people with DS as noted in an article called Assessing Down Syndrome BMI and Body Composition The preceding link will open in a new tab or window.  and another article called Body Composition and BMI Growth Charts in Children with Down Syndrome The preceding link will open in a new tab or window. . For now, BMI is the measure commonly used.

For a person with DS, weight management can be as challenging or even more challenging than in others. An article called Weight Management in Adults with Down Syndrome in our Resource Library, summarizes some of the issues and approaches to weight management.

However, the difficulty of weight management and the frequent failure despite great effort have led to the exploration of other treatments. 

One study, Sleeve Gastrectomy for Youth With Cognitive Impairment or Developmental Disability The preceding link will open in a new tab or window. , looked at weight loss (bariatric) surgery for adolescents. Eight of the participants had a cognitive impairment (CI) or developmental disability (DD) including three with Down syndrome. The study concluded: “Bariatric surgery may be a helpful tool for adolescents with severe obesity and CI/DD. They could benefit from the surgery as much as those with typical development and having CI/DD should not be used as a criterion to deny surgery.” 

Unfortunately, we were not able to find a study (or studies) describing the use of weight loss medication in people with DS. There are several medications available for weight loss but the knowledge of their use in people with DS is limited.

We have treated a small number of adults with DS with weight loss medication with some success. We think it is reasonable to consider medications for some individuals, especially when other methods have not been successful, particularly if they have health complications related to obesity. When the decision is made to consider a medication, a careful review of the medical history is warranted to help in the selection of the correct medication. The appropriate medication will vary from person to person. For example, some medications may be concerning for someone with gastrointestinal concerns, some for a person with history of anxiety, etc.

Below is a list of medications and their mechanisms of action as well as our experience and particular concern in DS.


Orlistat (Xenical, Alli)

  • Reduces fat absorption

  • A small number of patients have tried it. Soiling and incontinence associated with use may make this particularly challenging to use in some people with DS. 

Phentermine-topiramate (Qsymia)

  • Phentermine is a stimulant and topiramate is a seizure medication. Cause of weight loss not known.

  • A small number of patients have tried phentermine alone with some success. We have limited experience with topiramate by itself as a weight loss medication and have seen minimal benefit when taken alone. Topiramate is not FDA-approved to use by itself as a weight loss medication. We have had difficulty getting the combination medication approved by insurance. One option is to get prescriptions for each medication separately and take them together. In our limited experience, we have seen small amounts of weight loss when taken together. They can cause mood changes, anxiety, and cognitive impairment. There are a variety of other stimulants available that can also be prescribed for weight loss.

Naltrexone-bupropion (Contrave)

  • Naltrexone blocks opioid receptors (used to treat opioid and alcohol dependence and also used to treat self-injurious behavior (SIB) in people with intellectual disabilities). Bupropion (Wellbutrin) is an anti-depressant.

  • A small number of patients have tried it with limited success. It can be challenging to get it approved by insurance; an option is to prescribe each medication individually and take them together. We have significant experience using each one separately for SIB or depression and find them to be well-tolerated separately and together (in more limited experience). Neither medication is FDA-approved to be used by itself for weight loss.

Semaglutide (Wegovy) and liraglutide (Saxenda)

  • They activate the glucagon-like-peptide-1 receptor in the brain, regulating appetite and caloric intake. This category of medications is also used to treat diabetes mellitus. 

  • These medications are very expensive, and it is often difficult to get approval for insurance coverage. They are given via injection. Thyroid C-cell tumor is a possible side effect. Due to the limited coverage by insurance, we have had very limited opportunity to prescribe these medications. A recent study assessing semaglutide, Once-Weekly Semaglutide in Adults with Overweight or Obesity The preceding link will open in a new tab or window. , showed very significant weight loss; however, it has not been studied in people with DS.

Cellulose-citric acid hydrogel (Plenity)

  • Mixes with ingested food to increase volume promoting sense of satiety and fullness.

  • We have had no experience with it. Gastrointestinal side effects are common and likely to be limiting in people with DS (many of whom, in our experience, tend to have GI symptoms chronically).


Individuals taking medications for appetite and weight loss need to be monitored closely. We recommend working with a physician who is familiar with using weight loss medications and, if possible, also in caring for people with DS. A provider who is affiliated with a university medical system who specializes in weight management may be an option. A physician who is familiar with medications for weight will be aware of the contraindications.

Obesity is often more complicated to treat than “eat less and exercise more” which has been a standard for treatment for many years.  Further study of obesity both in people with and without DS will hopefully improve our understanding of cause(s) and treatments.

Additional information on medications for weight loss can be found on the Mayo Clinic website The preceding link opens in a new tab or window.  and Obesity Medicine website The preceding link opens in a new tab or window. .


This article was adapted from a Q&A developed in partnership with LuMind IDSC Foundation. This Q&A is available for free along with other Q&As at The preceding link opens in a new tab or window.


Please note: The information on this site is for educational purposes only and is not intended to serve as a substitute for a medical, psychiatric, mental health, or behavioral evaluation, diagnosis, or treatment plan by a qualified professional. We recommend you review the educational material with your health providers regarding the specifics of your health care needs.