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For people with Down syndrome, family members, caregivers and professionals.

Medications for Weight Loss

July 2022 | Brian Chicoine, MD - "Ask Dr. Chicoine" LuMind IDSC Foundation

The parent of an individual with Down syndrome asked a question about medications to treat obesity in a person who has not been significantly successful with diet and exercise despite many efforts. I have shared my response below.

Obesity and overweight as measured by body mass index (BMI) are more common in people with Down syndrome (DS). BMI, the measurement commonly used to assess weight status, is a calculation based on height and weight. A score of 18.5 to 24.9 is considered normal, 25-29.9 is “overweight,” 30-34.9 is class 1 obesity, 35-39.9 is class 2 obesity, and 40 and above is class 3. However, there is ongoing study and discussion as to the accuracy of BMI as a measurement in people with DS as noted in an article called Assessing Down Syndrome BMI and Body Composition and another article called Body Composition and BMI Growth Charts in Children with Down Syndrome. For now, BMI is the measure commonly used.

For a person with DS, weight management can be as challenging or even more challenging than in others. An article called Weight Management in Adults with Down Syndrome in our Resource Library, summarizes some of the issues and approaches to weight management.

However, the difficulty of weight management and the frequent failure despite great effort have led to the exploration of other treatments. 

One study, Sleeve Gastrectomy for Youth With Cognitive Impairment or Developmental Disability, looked at weight loss (bariatric) surgery for adolescents. Eight of the participants had a cognitive impairment (CI) or developmental disability (DD) including three with Down syndrome. The study concluded: “Bariatric surgery may be a helpful tool for adolescents with severe obesity and CI/DD. They could benefit from the surgery as much as those with typical development and having CI/DD should not be used as a criterion to deny surgery.” 

Unfortunately, we were not able to find a study (or studies) describing the use of weight loss medication in people with DS. There are several medications available for weight loss but the knowledge of their use in people with DS is limited.

We have treated a small number of adults with DS with weight loss medication with some success. We think it is reasonable to consider medications for some individuals, especially when other methods have not been successful, particularly if they have health complications related to obesity. When the decision is made to consider a medication, a careful review of the medical history is warranted to help in the selection of the correct medication. The appropriate medication will vary from person to person. For example, some medications may be concerning for someone with gastrointestinal concerns, some for a person with history of anxiety, etc.

Below is a list of medications and their mechanisms of action as well as our experience and particular concern in DS.


Orlistat (Xenical, Alli)

  • Reduces fat absorption.

  • A small number of patients have tried it. Soiling and incontinence associated with use may make this particularly challenging to use in some people with DS. 

Phentermine-topiramate (Qsymia)

  • Phentermine is a stimulant and topiramate is a seizure medication. Cause of weight loss not known.

  • A small number of patients have tried phentermine alone with some success. We have limited experience with topiramate by itself as a weight loss medication and have seen minimal benefit when taken alone. Topiramate is not FDA-approved to use by itself as a weight loss medication. We have had difficulty getting the combination medication approved by insurance. One option is to get prescriptions for each medication separately and take them together. In our limited experience, we have seen small amounts of weight loss when taken together. They can cause mood changes, anxiety, and cognitive impairment. There are a variety of other stimulants available that can also be prescribed for weight loss.

Lisdexamfetamine (Vyvanse)

  • One stimulant used for weight loss is lisdexamfetamine.

  • This medication has an indication for binge eating disorder (moderate to severe).

  • We do not have patients who have used this medication for weight loss. We do have patients who have used or are using it for attention-deficit/hyperactivity disorder who have noted the side benefit that it reduces their overeating.

Naltrexone-bupropion (Contrave)

  • Naltrexone blocks opioid receptors (used to treat opioid and alcohol dependence and also used to treat self-injurious behavior (SIB) in people with intellectual disabilities). Bupropion (Wellbutrin) is an anti-depressant.

  • A small number of patients have tried it with limited success. It can be challenging to get it approved by insurance; an option is to prescribe each medication individually and take them together. We have significant experience using each one separately for SIB or depression and find them to be well-tolerated separately and together (in more limited experience). Neither medication is FDA-approved to be used by itself for weight loss.

Semaglutide (Wegovy, Ozempic) and liraglutide (Saxenda)

  • They activate the glucagon-like-peptide-1 (GLP-1) receptor in the brain, regulating appetite and caloric intake. This category of medications is also used to treat diabetes mellitus. 

  • These medications are very expensive, and it is often difficult to get approval for insurance coverage. They are given via injection. Thyroid C-cell tumor is a possible side effect. Due to the limited coverage by insurance, we have had very limited opportunity to prescribe these medications. A recent study assessing semaglutide, Once-Weekly Semaglutide in Adults with Overweight or Obesity, showed very significant weight loss; however, it has not been studied in people with DS.

Cellulose-citric acid hydrogel (Plenity)

  • Mixes with ingested food to increase volume promoting sense of satiety and fullness.

  • We have had no experience with it. Gastrointestinal side effects are common and likely to be limiting in people with DS (many of whom, in our experience, tend to have GI symptoms chronically).

Tirzepatide (Mounjaro)

  • Activates GLP-1 and a protein in the body (glucose-dependent insulinotropic polypeptide, GIP) which increase insulin secretion, decrease glucagon secretion, increase insulin sensitivity, and delay gastric (stomach) emptying.

  • This medication is being studied for weight loss. However, currently, it only has FDA approval for type 2 diabetes mellitus. 

  • We have no experience with it.

Individuals taking medications for appetite and weight loss need to be monitored closely. We recommend working with a physician who is familiar with using weight loss medications and, if possible, also in caring for people with DS. A provider who is affiliated with a university medical system who specializes in weight management may be an option. A physician who is familiar with medications for weight will be aware of the contraindications.

One thing that is becoming clearer with the use of these medications is that they are treating a chronic condition. In the non-DS population, many people who achieve their weight goal and then stop the medication will have a rebound weight gain. It appears that use of the medication addresses the problem but not the underlying causes. Without significant lifestyle changes, stopping the medication will probably result in a weight increase again. Additionally, the beneficial effect of some of these medications on weight management may reduce (wear off) over time (even while still taking the medication).

Medications are best viewed as an adjunct to healthy eating and exercise activities. Building those healthy habits into their day can be a challenge for some individuals with DS (and some without DS). It has become clear that this is more than just “willpower” for most people, and there is much that needs to be learned of the brain chemistry, metabolism, etc. that contribute to weight management. This is even more true for people with DS as discussed in the weight management article from our Resource Library referenced above. However, some achieve and maintain their goals through a big commitment to change their nutrition and activity habits (which usually includes that others in the home do the same). It can be an upstream challenge in the face of societal and cultural norms for nutrition and activity.

Additional information on medications for weight loss can be found on the Mayo Clinic website and Obesity Medicine website.

Updated March 2023

This article was adapted from a Q&A developed in partnership with LuMind IDSC Foundation. This Q&A is available for free along with other Q&As at


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