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For people with Down syndrome, family members, caregivers and professionals.

The Utility of Anti-Tissue Transglutaminase Antibody-IgA (tTG-IgA) Testing for Celiac Disease in Adults with Down Syndrome

June 2014 | Chicoine, Parikh, Sulo, & Chicoine - American Journal of Clinical Medicine


Objectives: We assessed the diagnostic accuracy of the anti-tissue transglutaminase IgA antibody (tTG-IgA) test compared to esophagogastroduodenoscopy (EGD) in adults with Down  syndrome (DS).

Methods: Retrospective chart review of 152 adult patients with DS who were diagnosed with celiac disease (CD).

Results: Of these patients, 141 (92.8%) had a positive tTG-IgA and 11 (7.2%) had a negative result. Eighty-one (53.3%) did not have an EGD performed due to patient or legal representatives declining. Of the 71 who had a biopsy, the result of the tTG-IgA in 29 (40.8%) was a true positive, 35 (49.3%) a false positive, 2 (2.8%) a true negative, and 5 (7.0%) a false negative. The sensitivity was 85%, specificity 5%, positive predictive value 45%, and accuracy 43.7%.

Conclusions: The low specificity, accuracy, and positive predictive values of tTG-IgA in people with DS have significant clinical and financial implications in diagnosing, treating, and screening for CD in people with DS.

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