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For people with Down syndrome, family members, caregivers and professionals.

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Vision in Adults with Down Syndrome

Author: Lalithasree Chintam, MD - Family Medicine Resident, Advocate Lutheran General Hospital

People with Down syndrome (DS) experience many of the common eye problems that people without DS experience. Some people with DS experience these common eye problems more frequently and/or at an earli

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Use of Aspirin to Prevent Heart Attacks

Author: Brian Chicoine, MD - Medical Director, Adult Down Syndrome Center

We were sent a question about the use of aspirin to prevent heart attacks in people with Down syndrome. We have provided some information below. Please note that this information is for educational pu

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Alzheimer's Disease & Down Syndrome: A Practical Guidebook for Caregivers

Author: National Down Syndrome Society - Resource

The guidebook linked below was published by the National Down Syndrome Society "to help empower families and caregivers with knowledge about the connection between Down syndrome and Alzheimer

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Clinical Aspects and Biomarkers of Alzheimer's Disease in Down Syndrome

Author: Zis & Strydom - Free Radical Biology & Medicine (2017)

Abstract Alzheimer's disease (AD) may affect in excess of 90% of individuals with Down syndrome (DS) after age 60, due to duplication of the APP gene in trisomy of chromosome 21, with neuropat

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Dying Well with an Intellectual Disability and Dementia

Author: Service et al. - Journal of Dementia Care (2017)

Abstract Collaboration between palliative care, dementia care, hospice provision, and intellectual disability services is required rather than any one of these systems working in isolation. This is ne

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Self-Reported Presence and Experience of Pain in Adults with Down Syndrome

Author: de Knegt et al. - Pain Medicine (2017)

Abstract Objective: The aim was to examine whether the presence of pain (based on physical conditions and participants’ report) and self-reported pain experience in adults with Down syndrome

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Pain Perception in People with Down Syndrome: A Synthesis of Clinical and Experimental Research

Author: McGuire & Defrin - Frontiers in Behavioral Neuroscience (2015)

Abstract People with an intellectual disability experience both acute and chronic pain with at least the same frequency as the general population. However, considerably less is known about the pain pe

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Jenny's Diary: A Resource to Support Conversations about Dementia with People who have an Intellectual Disability

Author: Karen Watchman, Irene Tuffrey-Wijne, & Sam Quinn - University of Stirling

The resource linked below is a free to download booklet and set of postcards aimed at supporting conversations about dementia with people who have an intellectual disability. Access the Booklet &n

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Down Syndrome, Wolff-Parkinson-White Syndrome, and Bicuspid Aortic Valve

Author: Brian Chicoine, MD - Medical Director, Adult Down Syndrome Center

We were sent a question about Down syndrome and Wolff-Parkinson-White (WPW) syndrome and Bicuspid Aortic Valve. WPW is a heart condition in which there is an extra electrical pathway in the heart. The

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Fatigue

Author: Brian Chicoine, MD - Medical Director, Adult Down Syndrome Center

I recently had a couple inquiries about people with Down syndrome in their 50s or 60s who developed increased fatigue and falling asleep easily (these were new symptoms). Questions asked included: Is

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Down Syndrome and Heart Disease

Author: Brian Chicoine, MD - Medical Director, Adult Down Syndrome Center

If a 45-year-old man presents to the emergency room with chest pain, what is the big concern? Coronary ischemia (low blood flow to the heart muscle) and possibly myocardial infarction (heart attack).

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Pain Expression and Stimulus Localisation in Individuals with Down's Syndrome

Author: Hennequin et al. - The Lancet (2000)

Abstract Background:  Individuals with Down's syndrome do not always exhibit signs of distress in reaction to noxious stimuli comparable with the general population. This pilot study

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A Murine Model for Down Syndrome Shows Reduced Responsiveness to Pain

Author: Martinez-Cue et al. - NeuroReport

Abstract TS65DN mice have an extra chromosome that contains a segment of chromosome 16 homologous to the Down syndrome ‘critical region’ of human chromosome 21. Since pain transmis

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Please note: The information on this site is for educational purposes only and is not intended to serve as a substitute for a medical, psychiatric, mental health, or behavioral evaluation, diagnosis, or treatment plan by a qualified professional. We recommend you review the educational material with your health providers regarding the specifics of your health care needs.

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