Section Heading background Image

Resources

For people with Down syndrome, family members, caregivers and professionals.

Down Syndrome and Dementia: Advances in the Field

February 2020 | McGlinchey, McCallion, & McCarron - Current Opinion in Psychiatry (2020)

Abstract

Purpose of Review: People with Down syndrome represent the world's largest population with a genetic risk for Alzheimer's disease. This review will provide a short summary of what is known and will include recent findings from the field. 

Recent Findings: There has been an increasing focus on biomarker research in this population, with a number of studies presenting findings on promising new markers - Neurofilament Light (NfL) appears to be one such promising marker that has emerged. Imaging studies have increased our knowledge on the progression of Alzheimer's disease in this population. 

SummaryThe inclusion of people with Down syndrome in dementia research is vital from a scientific and an equity perspective. Recent advances in the field can have further impact with multisite, cross country collaborative efforts. For this to happen, instruments need to be validated across language and cultures. 

Full-text ($): https://doi.org/10.1097/YCO.0000000000000589

Please note: The information on this site is for educational purposes only and is not intended to serve as a substitute for a medical, psychiatric, mental health, or behavioral evaluation, diagnosis, or treatment plan by a qualified professional. We recommend you review the educational material with your health providers regarding the specifics of your health care needs.

Close