In April 2022, a clinical report was published in Pediatrics, a publication of the American Academy of Pediatrics. These pediatric guidelines are "designed to assist the pediatrician in caring for the child, adolescent, and family in whom a diagnosis of Down syndrome has been confirmed by chromosome analysis or suspected by prenatal screening."
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There is also an AAP Guide for Families .
For adults, please see the GLOBAL Medical Care Guidelines for Adults with Down Syndrome.